There are many options available especially with kids. Obviously if they are all young, then it is tough to travel, so you would probably wait until they are old enough to not run off or have to worry about changing diapers.

Once they are a little older then there are numerous options, it simply depends on where you want to go. If you go with another family or more people, then you can split the cost of renting a house.
The overall cost would be lower than staying in hotels.

Many folks take their whole family to Disney. For similar costs you can go to other countries and see the world instead of the Epcot version.

My wife and I plan on traveling with our new baby once she is around 2 years old or so. Some options we are kicking around are Australia with a stop to Hong Kong or Japan. Or we could go and visit relatives in Italy.